Brain's Weight Switch Found: Eat What You Want, Lose Weight With New Treatment - Neuroscience News
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This could be a groundbreaking advancement in obesity treatment that allows people to lose weight without compromising appetite or avoiding fats.

A new discovery reveals that astrocytes, star-shaped cells in the brain, play a key role in regulating fat metabolism and obesity. These cells act on a cluster of neurons, known as the GABRA5 cluster, effectively acting as a “switch” for weight regulation.

The MAO-B enzyme in these astrocytes was identified as a target for obesity treatment, influencing GABA secretion and thus weight regulation.

KDS2010, a selective and reversible MAO-B inhibitor, successfully led to weight loss in obese mice without impacting their food intake, even while consuming a high-fat diet, and is now in Phase 1 clinical trials.

  •  jarfil   ( @jarfil@beehaw.org ) 
    20•10 months ago

    Unless you don’t eat at all, the decision to eat is secondary to the decision to absorb energy from it.

    For example, I’ve been eating a “healthy diet” with about the same amount of exercise, for the last 3 years: first it kept my weight steady, then I lost 70 pounds in 3 months, then gained 10.

    The only difference: stress levels.

    People have been congratulating me for losing weight getting stressed out of my mind to the point of almost going crazy and killing myself. Thanks, but I was better before.