A new study suggests that a high-fat diet may impair memory by causing inflammatory effects and issues in cell-signaling management in the brain cells, especially as people age, but the omega-3 fatty acid DHA may help mitigate these effects. The research, focusing on microglia and hippocampal neurons, found that palmitic acid increased inflammation, while DHA protected against this effect but not against the loss of mitochondrial function induced by palmitic acid exposure.