The package managers and official repos for most distros would be better thought of as lego blocks to build an OS from - they have no concept of OS and application separation, and splitting installation of an OS across multiple physical drives doesn’t really make sense.
Application focused distribution methods with a clear separation from the OS like Flatpak or AppImage do support this.
AppImage - drag the .appimage wherever you want it.
Flatpak - supports system and per user installs (under home directory) by default. Additional installation directories can be configured, but I’m not sure if any of the GUIs expose this feature - so likely doesn’t currently pass your bar of not needing to use the command line at all.
The package managers and official repos for most distros would be better thought of as lego blocks to build an OS from - they have no concept of OS and application separation, and splitting installation of an OS across multiple physical drives doesn’t really make sense.
Application focused distribution methods with a clear separation from the OS like Flatpak or AppImage do support this.
AppImage - drag the .appimage wherever you want it.
Flatpak - supports system and per user installs (under home directory) by default. Additional installation directories can be configured, but I’m not sure if any of the GUIs expose this feature - so likely doesn’t currently pass your bar of not needing to use the command line at all.