In the AP, there are artifact cards and as an example i’ve linked to The Sickness card. It’s a pretty ordinary item, all things considered, and isn’t actually as powerful as you might expect of a Lv20 magic item in the hands of a low level character. But it’s still useful! It grants a nice (if niche) passive resistance effect to diseases. Depending on your build, you might outgrow the passive bonuses, but that’s not the end of the card’s usefulness.

The card also has an enemy facing effect with a DC, something that is usually a death sentence for item’s usability. Usually you’ll have to retire items that do that a level or two after finding them (eg. Dread rune, yellow musk vial, etc.) because enemy saves are always rising, while the item’s DCs never can. However, you might notice something about this item; It scales its DC with your class DC. It’s just… usable forever.