To anyone not scared off by this, my main mail server is based around this guide. I make some changes, but I think it does a good job explaining the various moving parts and a way of setting them up:

https://workaround.org/ispmail/bullseye/

There are also some easy to deploy dockerized projects that I hear are good like mailcow.

https://mailcow.email/

Or to for the simplest experience, you could use panel software like cpanel or plesk or something that does e-mail, web hosting, etc all in one package. I manage a plesk install that works… okay.

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Managing e-mail is a bit of a pain, especially the initial setup, and finding clean IP spaces. But honestly I spend very little time managing mine. Months go by where I basically do nothing.

…then microsoft or google do something stupid, or a user gets infected and send some spam I don’t catch, and I’ve got a day of hecticly trying to get mail flowing again while users send me nastygrams