Not too long ago, regulations on CBD changed in Germany leading to a plethora of products containing it. As someone who occasionally needs pain medication, I tried some of the products to avoid regular pain killers (ibu). Especially on days with lighter pain, I wished for an alternative to the sledgehammer meds. But I was left standing in the rain. I didn’t feel any effect. That’s why I would love to hear from your experiments and experience.

  •  Hot Saucerman   ( @dingus@lemmy.ml ) 
    10•1 year ago

    I’m having trouble finding it, but I ran across a study a few months ago whose results pointed to greater pain relief gains when CBD was consumed with THC, and that both substances alone do less to “relieve” pain.

    I wouldn’t say it helps relieve pain as much as it lets you be distracted from pain.

    Also, personally, when I have used CBD on it’s own, it never did anything for me at all. It only ever worked in combination with THC.

    Finally, people taking other medications need to be careful about taking CBD.

    The vast majority of medications are broken down by enzyme CYP3A4, an enzyme that CBD inhibits.

    I am taking a life-saving/life-altering medication to manage a severe disease. It is handled in my body by CYP3A4. Meaning I can really fuck up my medication dosage by taking CBD on its own, because it will inhibit the ability of CYP3A4 to ingest the drug.

    User pizza_rolls@kbin.social helpfully pointed out that grapefruit inhibits CYP3A4 as well, so if you’re not supposed to eat grapefruit, you should probably also avoid CBD. I hadn’t even made that connection myself, very astute, pizza_rolls!

      •  Hot Saucerman   ( @dingus@lemmy.ml ) 
        3•1 year ago

        Absolutely. I am glad I did the research myself and stumbled across this fact, because when I was prescribed this drug I bought a lot of CBD chocolates, thinking they would help. I was surprised that sooooooooo many prescribed medications use CYP3A4 as a pathway to enter the body, and how this isn’t discussed more often. I really haven’t seen very much discussion at all about how CBD can inhibit the effectiveness of a whole host of prescription drugs.

        Anyway, cheers, glad to be sharing the info!

      •  Hot Saucerman   ( @dingus@lemmy.ml ) 
        1•1 year ago

        If your medication says to avoid grapefruit, then you probably should not take CBD

        I didn’t even make that connection, but yeah, exactly! Grapefruit inhibits the exact same enzyme. That’s a really good way to know, I’m going to add that to my post.