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Syldon ( Syldon@feddit.uk )  to United Kingdom@feddit.ukEnglish · 3 years ago

Girl, 8, first UK transplant patient not to need life-long drugs in breakthrough

www.standard.co.uk

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Girl, 8, first UK transplant patient not to need life-long drugs in breakthrough

www.standard.co.uk

Syldon ( Syldon@feddit.uk )  to United Kingdom@feddit.ukEnglish · 3 years ago
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Aditi Shankar will not need to take drugs for life in pioneering transplant treatment at Great Ormond Street Hospital
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  • HubertManne ( HubertManne@kbin.social ) 
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    3 years ago

    Amazing but needing a bone marrow transplant from the same person who donated the organ makes this unlikely to become the norm. Its only stem cells they need so maybe if we can improve the stem cell reversion thing.

    • Syldon ( Syldon@feddit.uk ) OP
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      3 years ago

      I find the process amazing, more so if it can be cascaded across many donors.

    • tony ( tony@lemmy.hoyle.me.uk ) 
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      3 years ago

      It could do… apparently live donors are about 30% of transplants now. In those cases it’s not a huge extra step to get some bone marrow.

      • HubertManne ( HubertManne@kbin.social ) 
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        3 years ago

        I heard bone marrow is really aweful and requires a lot of recovery but maybe that is just the recieving end or something.

        • nikhil ( nikhil@beehaw.org ) 
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          3 years ago

          That was back in the day when it had to be extracted from inside the thigh bone. When I donated 10 years ago, it was a few injections upfront to increase your natural stem cell count in the blood, followed by a 4 hr at a clinic to extract them using a dialysis machine. The narrative about bone marrow being painful needs to die. It might be de motivating potential donors.

          • HubertManne ( HubertManne@kbin.social ) 
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            3 years ago

            oh thats wonderful. Yeah I think I have holdovers from when the procedure first came out.

            • Nashua ( Nashua@programming.dev ) 
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              3 years ago

              It’s called periphery blood stem cell donation apparently. Was curious and went looking. Linked in case you’re curious too.

              There is another method that that isn’t really applicable here, which comes from donated umbilical cords and placentas that would otherwise be thrown away.

              • HubertManne ( HubertManne@kbin.social ) 
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                3 years ago

                you know I did a search and saw those but was not sure it applied since the article specifically said bone marrow which made me think the other stem cells would not suffice.

                • Nashua ( Nashua@programming.dev ) 
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                  3 years ago

                  That may just be the reporter simplifying to match the newspaper’s target audience.

                  There are different types of stem cell, true. My guess is that they’re talking about hematopoietic stem cells (hence bone marrow), and those are also found in the blood stream and collectible through periphery donation. The first link actually talks about PBSC donation in terms of bone marrow transplants in the opening paragraph.

                  We’ll find out for sure when they publish the journal next week :)

  • 38fhh2f8th5819c7 ( 38fhh2f8th5819c7@lemm.ee ) 
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    3 years ago

    Any haematologists / immunologoists here? Does she run the risk of GVHD after this?

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